Diagnostics

A wide variety of diagnostic and cell culture applications involve spotted or coated proteins on plates, stripes, beads, or nano particles. LEUKOCARE’s Stabilizing and Protecting Solutions (SPS) physically stabilize spotted proteins, prevent aggregation and improve specificity of antibody / antigen recognition. SPS reduces off target activities, extends shelf-life and enables sterilization of the diagnostic devices by irradiation. While sterilization of proteins in in vitro diagnostic applications is primarily relevant for shelf-life, it is essential for product safety in in vivo diagnostic applications.

Moreover, LEUKOCARE applies its technologies for instance in projects using antibody coated devices to capture rare circulating cells from patients peripheral blood such as circulating tumor cells (CTCs) for diagnostic or therapeutic purpose or fetal cells from mother’s blood for pre-natal diagnostics.

LEUKOCARE’s Stabilizing and Protecting Solutions (SPS) consist of physiological and non-toxic small molecule ingredients generally recognized as safe (GRAS status), which are individually customized to the specific needs of each substrate or product. SPS is sugar and protein free.

LEUKOCARE also offers services to implement its patented SPS technologies into diagnostic devices with respect to:

• Identification of suitable effector molecules
• Coupling the effector molecules to the device surface
• Stabilizing the effector molecules in absence of water
• Terminally sterilizing the diagnostic device